Scleroderma is caused when there is an excessive deposition of collagen in the skin or other parts of the human body. One of the deadliest of all kinds of chronic diseases, Scleroderma is usually not fatal. However severe types of Scleroderma can affect some of the major organs in the human body. Scleroderma is one of the most common autoimmune diseases in human beings.
Like most diseases of this group, Scleroderma is characterized by fibrosis forming on the tissues and organs of the body. The antibody meant for protecting these organs then behaves in an opposite manner to destroy the muscles and tissues of the affected area. Although the causes for Scleroderma are not clear, it is believed that, both genes and environment play an important role in causing the disease.
Causes of Scleroderma
Referred as an autoimmune disease, Scleroderma can be inherited from the family tree. Polymorphisms can increase the severity of Scleroderma, to a great extent. A large number of organic solvents and cytomegalovirus are often related to Scleroderma.
Many medical practitioners are of the opinion that, fetal cells which circulate in the maternal blood can result into autoimmune phenomenon in human beings. People who suffer from poor kidney conditions and continuous renal failure can also fall victims to Scleroderma.
Sometimes serious illnesses deserve bleomycin and taxane chemotherapy. Exposure to these chemicals can cause severe Scleroderma.
Symptoms of Scleroderma
Blood vessels, skin and other internal organs can suffer from the early symptoms of Scleroderma. There is usually a noticeable scar on the external part of the skin. Sometimes, the surface may also harden up. If Scleroderma has attacked the esophagus, there may be a contraction in the tract.
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Mild Scleroderma usually leaves external symptoms on the skin and does not affect the internal organs. However, extreme cases of Scleroderma can result into Raynaud's Phenomena in patients. The patient can suffer from a discoloring of the fingers, when exposed to chilly weather. Regular medication and certain exercises can bring about temporary improvement in patients suffering from Scleroderma.
Diagnosis of Scleroderma
Most patients of Scleroderma are asked to undergo regular blood tests and biopsy tests. If the detailed blood test reveals the presence of anti centromere and anti-topoisomerase antibodies, one is said to be suffering from Scleroderma. A biopsy test on the other hand, can clearly show inflammation and damage of the tissues in the affected area.
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